Open Access
J Oral Med Oral Surg
Volume 30, Number 2, 2024
Article Number 10
Number of page(s) 2
Published online 23 May 2024

© The authors, 2024

Licence Creative CommonsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

A 55-years old woman reported intra-oral lesion of the lower lip occurring approximately 2 months after nasolabial folds dermal filler injections (Radiesse®, Bioform Inc, USA). No drugs intake nor systemic diseases were referred by the patient.

At the clinical examination a yellowish submucosal painless mass of approximately 15mm has been detected on the intraoral left side of the inferior lip, covered by clinically healthy oral mucosa. The lesion appeared soft and elastic on palpation while no cervical lymphadenopathy was detectable.

A superficial incision was performed along the oral mucosal aspect of the lower lip, exposing white and rubbery consistency material which was attached to the surrounding connective tissue. An incisional biopsy was performed, and the histopathological examination identified finely granular, yellowish / non-dyeable, partly birefringent material, consistent with exogenous material.

A definitive diagnosis of foreign body reaction to calcium hydroxyapatite, contained in the dermal filler, was made. The lesion underwent complete spontaneous regression within eight months, with no further surgical intervention.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Conflict of Interests

Authors have no conflict of interests to disclose.

Data availability statement

The data that support the findings of this study are available on request from the corresponding author, [NL].

Author contribution statement

N.L. wrote the manuscript, collected the clinical data and followed the patient during diagnosis and treatment G.L. reviewed the manuscript and followed the patient during diagnosis and treatment.

Informed consent

The study was conducted in compliance with the recognized international standards, including the principles of the Declaration of Helsinki. Data and samples were collected under patient's informed written consent, guaranteeing anonymity.

All Figures

thumbnail Fig. 1

Submucosal lesion of the lower lip.

In the text
thumbnail Fig. 2

Histopathological image of the sample.

In the text
thumbnail Fig. 3

Complete resolution of the lesion at 8 months.

In the text

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.