Causes of pigmented lesions of the oral mucosa according to their origin.
|Physiological coloration||Melanic ranges in melanodermic patients|
|Coloration related to a systemic disease||Laugier–Hunziker syndrome|
|Acromegaly, McCune–Albright syndrome, Cushing’s disease, or hyperthyroidism|
|Peutz Jeghers syndrome|
|Coloration related to a chronic inflammatory condition||Oral lichen planus
|Coloration caused by a tumor||Kaposi sarcoma|
|Exogenous coloring||Foreign body (graphite or tar)|
|Consumption of certain foods: Betel nut (Areca)|
|Exposure to heavy metals: Bismuth, lead, silver, or mercury|
|Melanosis caused by smoking|
|Coloration of traumatic origin||Melanoacanthoma|
|Petechiae, purpura, bruise, or hematoma|
|Coloration of iatrogenic origin||Minocycline|
|Chemotherapy treatment: Busulfan and doxorubicin
|Vascular/hematological coloration||Varicose veins|
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