J Oral Med Oral Surg
Volume 28, Number 2, 2022
|Number of page(s)||6|
|Published online||26 May 2022|
Myofibroblastic sarcoma of the oral cavity: a diagnostic dilemma and report of two cases
Oral Medicine and Oral Pathology Unit, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
2 Pathology Department, School of Medical Sciences, Universiti Sains Malaysia Kubang Kerian, 16150 Kelantan, Malaysia
3 Hospital USM, Health Campus, USM, 16150, Kubang Kerian Kelantan, Malaysia
* Correspondence: firstname.lastname@example.org
Accepted: 18 November 2021
Introduction: Myofibroblastic sarcoma is designated as a low-grade malignancy, commonly affecting the deep soft tissue of the head and neck. Despite being classified as low-grade, myofibroblastic sarcoma with high-grade features have been reported. Observations: Two such cases affecting the oral cavity, which were diagnosed as different entities upon biopsy, were observed. Case 1 presented as multiple, well-circumscribed soft tissue swellings of the tongue and alveolar mucosa and was diagnosed as synovial sarcoma. Case 2 manifested as a large extensive osseous lesion of the maxilla and was diagnosed as an inflammatory myofibroblastic tumour. Conclusion: Myofibroblastic sarcoma with high-grade features remains a diagnostic dilemma due to its overlapping features with other spectra of fibroblastic/myofibroblastic tumours and lack of consensus regarding its classification as a separate entity. Establishing the definitive diagnosis requires adequate tumour sampling and a systematic clinicopathological approach.
Key words: Myofibroblastic sarcoma / high grade / fibroblastic/myofibroblastic tumours / oral cavity / case report
© The authors, 2022
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