| Issue |
J Oral Med Oral Surg
Volume 26, Number 2, 2020
|
|
|---|---|---|
| Article Number | 24 | |
| Number of page(s) | 6 | |
| Section | Article original / Original article | |
| DOI | https://doi.org/10.1051/mbcb/2020012 | |
| Published online | 05 June 2020 | |
Original Article
Validation of a rabbit model of irradiated bone healing: preliminary report
1
Léon Bérard Cancer Center, Head and Neck Unit, Surgery Department, 28 rue Laennec, 69008 Lyon, France
2
Labtau – Inserm 1032, 151 cours Albert Thomas, 69008 Lyon, France
3
ICE (Experimental Surgery Institute) Léon Bérard Cancer Center, 28 rue Laennec, 69008 Lyon, France
4
University Claude Bernard Lyon I, Lyon, France
* Correspondence: anne-gaelle.bodard@lyon.unicancer.fr
Received:
15
November
2019
Accepted:
14
April
2020
Introduction: External radiotherapy can lead to severe bone alteration. The aim of this pilot study was to validate a model for assessment of postextractional bone healing in the irradiated rabbit mandible. Material and method: The radiation protocol consisted of 5 sessions delivering 8.5 Gy each. Surgery was performed immediately after completion of radiotherapy. Sacrifices were performed from Day 0 to Day 42. Results: The bone mineral density and the trabecular number were decreased after radiotherapy whereas trabecular separation increased. The main differences between irradiated and non-irradiated rabbits were observed at Day 28 and 42. Discussion: Radiation seems to cause a delay in bone healing. It decreases bone quality and bone mineral density. Five sessions seem to be a valuable compromise between tissues effect and feasibility of the experiment. Conclusion: This model seems to be valuable for evaluating postextractional bone healing in the irradiated rabbit mandible.
Key words: External radiotherapy / bone healing / animal model
© The authors, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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