J Oral Med Oral Surg
Volume 26, Number 2, 2020
|Number of page(s)||6|
|Section||Article original / Original article|
|Published online||05 June 2020|
Validation of a rabbit model of irradiated bone healing: preliminary report
Léon Bérard Cancer Center, Head and Neck Unit, Surgery Department, 28 rue Laennec, 69008 Lyon, France
2 Labtau – Inserm 1032, 151 cours Albert Thomas, 69008 Lyon, France
3 ICE (Experimental Surgery Institute) Léon Bérard Cancer Center, 28 rue Laennec, 69008 Lyon, France
4 University Claude Bernard Lyon I, Lyon, France
* Correspondence: email@example.com
Accepted: 14 April 2020
Introduction: External radiotherapy can lead to severe bone alteration. The aim of this pilot study was to validate a model for assessment of postextractional bone healing in the irradiated rabbit mandible. Material and method: The radiation protocol consisted of 5 sessions delivering 8.5 Gy each. Surgery was performed immediately after completion of radiotherapy. Sacrifices were performed from Day 0 to Day 42. Results: The bone mineral density and the trabecular number were decreased after radiotherapy whereas trabecular separation increased. The main differences between irradiated and non-irradiated rabbits were observed at Day 28 and 42. Discussion: Radiation seems to cause a delay in bone healing. It decreases bone quality and bone mineral density. Five sessions seem to be a valuable compromise between tissues effect and feasibility of the experiment. Conclusion: This model seems to be valuable for evaluating postextractional bone healing in the irradiated rabbit mandible.
Key words: External radiotherapy / bone healing / animal model
© The authors, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.