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Up-to Date Review And Case Report

Table I

Clinical and pathological characteristics of benign spindle cell tumors.

  Solitary myofibroma Fibromatosis Nodular fasciitis Solitary fibrous tumor
Age Predilection Up to 4th decade Children & young Adults 20–40 years Adults
Intraoral site Mandible Paramandibular soft tissue   Buccal mucosa
Capsule Well-circumscribed Poorly circumscribed Well-circumscribed Well-circumscribed
Cellular component Plump spindle-shaped cells with eosinophilic cytoplasm Plump spindle-shaped cells, more cellular at periphery Plump spindle-shaped cells Round to spindle
Arrangement Biphasic Long Streaming fascicles Tissue culture/feathery Short fascicles to patternless
Stromal Characteristics Hyalinized at periphery Variable amounts of collagen Myxoid (early) to hyalinised (long-standing)
Mucopolysaccharide rich
Myxoid areas
Prominent hyalinisation
Vascularity HPC-like vascular pattern Thin walled vessels Haemorrhagic areas with hemosiderin deposition Focal HPC-like vascular pattern
Inflammation Absent Scattered lymphocytes at periphery Scattered lymphocytes in centre Absent
Alcian blue stain Negative Negative Stroma is Positive Negative
αSMA +++ +++ +++
Desmin Rare +/–
CD-34 +++
β-Catenin +++ (nuclear) +++ (nuclear)

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