Open Access
Table I
Clinical and pathological characteristics of benign spindle cell tumors.
| Solitary myofibroma | Fibromatosis | Nodular fasciitis | Solitary fibrous tumor | |
|---|---|---|---|---|
| Age Predilection | Up to 4th decade | Children & young Adults | 20–40 years | Adults |
| Intraoral site | Mandible | Paramandibular soft tissue | Buccal mucosa | |
| Capsule | Well-circumscribed | Poorly circumscribed | Well-circumscribed | Well-circumscribed |
| Cellular component | Plump spindle-shaped cells with eosinophilic cytoplasm | Plump spindle-shaped cells, more cellular at periphery | Plump spindle-shaped cells | Round to spindle |
| Arrangement | Biphasic | Long Streaming fascicles | Tissue culture/feathery | Short fascicles to patternless |
| Stromal Characteristics | Hyalinized at periphery | Variable amounts of collagen | Myxoid (early) to hyalinised (long-standing) Mucopolysaccharide rich |
Myxoid areas Prominent hyalinisation |
| Vascularity | HPC-like vascular pattern | Thin walled vessels | Haemorrhagic areas with hemosiderin deposition | Focal HPC-like vascular pattern |
| Inflammation | Absent | Scattered lymphocytes at periphery | Scattered lymphocytes in centre | Absent |
| Alcian blue stain | Negative | Negative | Stroma is Positive | Negative |
| αSMA | +++ | +++ | +++ | – |
| Desmin | – | – | Rare | +/– |
| CD-34 | – | – | – | +++ |
| β-Catenin | – | +++ (nuclear) | – | +++ (nuclear) |
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