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Home All issues Volume 24 / No 1 (January 2018) J Oral Med Oral Surg, 24 1 (2018) 11-21 Full HTML
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Table IV

Critical analysis of the literature on the efficacy of botulinum toxin in the management of hypersalivation in adults with neuro-degenerative neurological diseases.

Reference Objective Type of study No. BT dose Duration Judgment criteria Muscle site salivary gland Validity
Mancini, 2002 [26] Efficiency: injection versus placebo Rand, DB, CT 20 450 U, Dysport** 3 months Subjective: DFSS, EI P + Sb S
Guidubaldi, 2011 [27] Efficacy: A and B toxin Injection versus placebo Rand, DB, CT, cross-over 14 250 U, Dysport**, 2500 U, Neurobloc** NS Subjective: DFSS, Objective: cotton salivary test P + Sb S, B>A
Chinnapongse, 2012 [28] Efficiency: three injections versus placebo Rand, DB, CT, Multicenter 54 1500 U, 2500 U, 3500 U, Neurobloc** 5 months Subjective: DFSS, EI P + Sb S
Dogu, 2004 [29] Efficacy: Injection with US versus without Rand, CT 15 30 U, Boto* 3 months Subjective: VAS, Objective: cotton salivary test P S, US>without
Lipp, 2003 [30] Efficiency: Injection versus placebo Rand, DB, CT, prospective 27 18.75 U, 37.5 U, 75 U, Dysport* 6 months Subjective: VAS, Objective: Cotton salivary test P S
Lagalla, 2006 [31] Efficiency: injection versus placebo Rand, DB, CT 32 50 U, Botox* 1 month Subjective: DFSS, Objective: Cotton salivary test P S
Kalf, 2007 [32] Efficacy: Parotid versus submandibular Injection Rand, CT 17 150 U, Dysport* 1 month Subjective: VAS, DFSS P + Sb S, Submandibular>parotid
Mazlan, 2015 [33] Effective Doses Rand, DB, CT 30 50 U, Botox* 6 months Subjective: DFSS, Objective: Cotton salivary test P + Sb S

Rand: randomized; DB: double-blind; CT: clinical trial; U: Unit; No.: number; BT: botulinum toxin; Q: questionnaire; DQ: drooling quotient; P: parotid; Sb: submandibular; NS: not significant; S: significant.

*

By injection.

**

In total.

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