Therapeutic uses and efficacy of botulinum toxin in orofacial medicine | Journal of Oral Medicine and Oral Surgery

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Table III

Critical analysis of the literature on the efficacy of botulinum toxin in the management of overdrooling in children with cerebral motor problems.

Reference	Objective	Type of study	No.	BT dose	Duration	Judgment criteria	Muscle site salivary gland	Validity
Reid, 2008 [21]	Efficiency: Injection versus no injection	Rand, CT, multicenter	48	100 U	12 months	Subjective: Q ° parents	P + Sb	S
Reid, 2008 [21]	Efficiency: Injection versus no injection	Rand, CT, multicenter	6–18 years	Botox^**	12 months	Subjective: Q ° parents	P + Sb	S
Alrefai, 2008 [22]	Efficacy: Injection versus placebo	Rand, DB, CT	24	240 U	4 months	Subjective: Q ° nurse	P + Sb	S
Alrefai, 2008 [22]	Efficacy: Injection versus placebo	Rand, DB, CT	21 months to 7 years	Dysport^**	4 months	Subjective: Q ° nurse	P + Sb	S
Jongerius, 2004 [23]	Efficiency: injection versus Scopolamine	Rand, CT	45	50 U	24 months	Subjective: Q ° parents	Sb	S
Jongerius, 2004 [23]	Efficiency: injection versus Scopolamine	Rand, CT	3–17 years	Botox^*	24 months	Objective: DQ	Sb	Injection>scopolamine
Suskind, 2002 [24]	Efficacy: injection in different glands	CT, prospective	22	30 U	1 month	Objective: DQ	P + Sb	S
Suskind, 2002 [24]	Efficacy: injection in different glands	CT, prospective	8–21 years	Botox^*	1 month	Cotton salivary test	P + Sb	NS difference
Basciani, 2011 [25]	Efficiency: 3 different doses versus placebo	Rand, CT, prospective	27	1500 U, 3000 U, 5000 U, Neuroblo^**	3 months	Subjective: Q ° parents	P + Sb	S
Basciani, 2011 [25]	Efficiency: 3 different doses versus placebo	Rand, CT, prospective	6 months to 7 years	1500 U, 3000 U, 5000 U, Neuroblo^**		Objective: number of bottles	P + Sb	S

Rand: randomized; DB: double-blind; CT: clinical trial; U: unit; No.: number; BT: Botulinum toxin; Q: questionnaire; DQ: drooling quotient; P: parotid; Sb: submandibular; NS: not significant; S: significant.

By injection.

^**

In total.

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