Therapeutic uses and efficacy of botulinum toxin in orofacial medicine | Journal of Oral Medicine and Oral Surgery

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Table II

Critical analysis of the literature on the efficacy of botulinum toxin in the management of mouth opening limitation.

Reference	Objective	Type of study	No.	BT dose	Duration	Judgment criteria	Muscle site	Validity
Fietzek, 2009 [14]	Efficiency: MO increase	Rand, DB, CT 2 centers	11	5000 U Neurobloc^**	6 weeks	Objective: IDS, saliva rate, MO	M	S
Guarda-Nardini, 2012 [15]	Efficacy: decrease in pain and increase MO	Rand, CT; SB	30	150 U Dysport^*	3 months	Subjective: VAS	M + T	S
Guarda-Nardini, 2012 [15]	Efficacy: decrease in pain and increase MO	Rand, CT; SB	30	150 U Dysport^*	3 months	Objective: MO	M + T	S
Kurtoglu, 2010 [16]	Efficiency: decreased pain and increased MO	Rand, DB, CT	24	30 U Botox^*	1 month	Subjective: VAS	M + T	S
Kurtoglu, 2010 [16]	Efficiency: decreased pain and increased MO	Rand, DB, CT	24	30 U Botox^*	1 month	Objective: MO with EMG	M + T	S
Denglehem, 2010 [17]	Efficacy: decreased pain	Rand, DB, CT	30	50 U Botox^*	1 month	Subjective: VAS with pressure	M + T	S
Denglehem, 2010 [17]	Efficacy: decreased pain	Rand, DB, CT	30	50 U Botox^*	1 month	Objective: Muscular activity with EMG	M + T	S
Sidebottom, 2012 [18]	Efficiency: decreased pain and increased MO	Prospective, statistical analysis	62	50 U Dysport^*	3 weeks	Subjective: VAS	M + T + P	S
Sidebottom, 2012 [18]	Efficiency: decreased pain and increased MO	Prospective, statistical analysis	62	50 U Dysport^*	3 weeks	Objective: MO		S

Rand: randomized; DB: double-blind; SB: single-blind; CT: clinical trial; U: Unit; No.: number; BT: Botulinum toxin; VAS: visual analog scale; MO: mouth opening; IDS: interdental space; EMG: electromyogram; M: masseter; T: temporal; P: medial pterygoid; US: unspecified; S: significant.

By injection.

^**

In total.

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