OI Sillences classification, completed by Glorieux .
|Type||Clinical severity||Typical features||Typically associated mutations*|
|I||Mild non-deforming osteogenesis imperfecta||Normal height or mild short stature; blue sclera; no dentinogenesis imperfecta||Premature stop codon in COL1A1|
|II||Perinatal lethal||Multiple rib and long-born fractures at birth; pronounced deformities; broad long bones; low density of skull bones on radiographs; dark sclera||Glycine substitutions in COL1A1 or COL1A2|
|III||Severely deforming||Very short; triangular face; severe scoliosis; greyish sclera; dentinogenesis imperfecta||Glycine substitutions in COL1A1 or COL1A2|
|IV||Moderately deforming||Moderately short; mild to moderate scoliosis; grey or white sclera; dentinogenesis imperfecta.||Glycine substitutions in COL1A1 or COL1A2|
|V||Moderately deforming||Mild to moderate short stature; dislocation of radial head; mineralized interosseous membrane; hyperplastic callus; white sclera; no dentinogenesis imperfecta||Unknown|
|VI||Moderately to severely deforming||Moderately short; scoliosis; accumulation of osteoid in bone tissue, fish-scale pattern of bone lamellation; white sclera; no dentinogenesis imperfecta||Unknown|
|VII||Moderately deforming||Mild short stature; short humeri and femora; coxa vara; white sclera; no dentinogenesis imperfecta||Unknown|
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