J Oral Med Oral Surg
Volume 25, Number 1, 2019
|Number of page(s)
|Article pédagogique / Educational article
|22 February 2019
Management of mTOR inhibitors oral mucositis: current state of knowledge
Oral Surgery Department, Pitié Salpetriere
2 Faculty of Odontology, Paris Diderot
3 Center of Immunology and Infectious Diseases (CIMI-Paris)
* Correspondence: email@example.com
Accepted: 28 August 2018
Introduction: Mucositis is a well-known side effect of classic anticancer treatments (chemotherapy and radiotherapy). Thanks to the major developments in personalizing treatments through the development of targeted treatment, various specific intraoral lesions have been described. Purpose: mTOR inhibitors are targeted anticancer treatments that are used to treat various cancer types. They can cause intraoral ulcerations that can be serious, and that can lead to a dose reduction or the anticancer treatment being stopped altogether. The management of these disabling and painful lesions is a major part of ensuring the efficiency of the cancer treatments. The objective of this article is to evaluate the current knowledge about the different treatments used nowadays, especially the preventive treatments. Conclusion: An efficient management of the lesions is a major part of the management of patients treated with mTOR inhibitors and should be carried out by the oral cavity specialists.
Key words: mTOR inhibitor / stomatitis / targeted anticancer treatments
© The authors, 2019
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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