J Oral Med Oral Surg
Volume 24, Number 4, December 2018
|Page(s)||182 - 186|
|Section||Cas clinique et revue de la littérature / Up-to date review and case report|
|Published online||17 December 2018|
Up-to Date Review And Case Report
Giant-cell granuloma: 2 case reports
Dentistry Department, GH Pitié-Salpétrière-Charles-Foix, Ivry-sur-Seine, France
2 ENT Department, GH Kremlin-Bicêtre, Le Kremlin-Bicètre, France
* Correspondence: firstname.lastname@example.org
Accepted: 17 April 2018
Introduction: Giant-cell granuloma (GCG) is a benign tumor occurring almost exclusively in the jaws. These lesions remain rare but can sometime have an aggressive behavior. In this article, we will describe and follow two cases of GCG. Observations: The first case is a referred female patient, who presents a mandibular swelling. Its clinical and radiological aspects lead us to do a biopsy, with a histological result of GCG. The second case is a patient with a terminal kidney failure, referred for a buccal swelling in the upper left jaw. The cone-beam computed tomography X-ray shows a compartmentalized lesion with blurry limits. An excisional biopsy is performed and the histological diagnosis is a GCG. Discussion: Although the first patient suffers from no systemic disease, the second one presents a terminal kidney failure resulting in a chronic hyperparathyroidism. Hyperparathyroidism can activate osteoclastic resorption and create bone lesions such as brown tumors. Conclusion: The slow and asymptomatic growth of these lesions often result in a late diagnosis. It should be kept in mind as a differential diagnosis when dealing with an osteolytic lesion of the jaws with no clear etiology, especially if hyperparathyroidism or kidney failure is associated.
Key words: giant-cell granuloma / brown tumors / diagnosis
© The authors, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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