| Issue |
J Oral Med Oral Surg
Volume 24, Number 4, December 2018
|
|
|---|---|---|
| Page(s) | 187 - 191 | |
| Section | Cas clinique et revue de la littérature / Up-to date review and case report | |
| DOI | https://doi.org/10.1051/mbcb/2018021 | |
| Published online | 17 December 2018 | |
Up-to Date Review And Case Report
Rare agressive form of giant-cell granuloma: a three years follow-up case report and discussion about medical therapeutic solutions
1
Service d'Odontologie Restauratrice et Chirurgicale, CHU Hôtel-Dieu, Nantes, France
2
Service de Chirurgie Maxillo-Faciale et Stomatologie, CHU Hôtel-Dieu, Nantes, France
3
Service d'Anatomie et Cytologie Pathologiques, CHU Hôtel-Dieu, Nantes, France
* Correspondance: gregoire.huguet@live.fr
Received:
20
September
2017
Accepted:
6
July
2018
Introduction: Central giant cell granuloma (CGCG) is a rare and benign intraosseous lesion that usually occurs in the mandible and the maxilla. It might be aggressive. Nowadays, several treatments exist. Observation: This case report, with a three years follow-up, was about an aggressive and recurring form of CGCG exclusively managed by surgical approach. Comments: Several pharmacologic approaches are possible (intralesional injections of glucocorticoids, administration of calcitonin, alpha-2a interferon, denosumab) and could be an interesting alternative or complement to the surgical management when CGCG is aggressive, recurring, or non resectable. Conclusion: Surgical approach is the gold standard for the treatment of CGCG but sometimes, pharmacologic approaches could be proposed. According to the scientific literature, denosumab appears as a reliable and effective treatment but more prospective studies are needed.
Key words: central giant cell ganuloma / denosumab / mandible
© The authors, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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