J Oral Med Oral Surg
Volume 24, Number 4, December 2018
|Page(s)||187 - 191|
|Section||Cas clinique et revue de la littérature / Up-to date review and case report|
|Published online||17 December 2018|
Up-to Date Review And Case Report
Rare agressive form of giant-cell granuloma: a three years follow-up case report and discussion about medical therapeutic solutions
Service d'Odontologie Restauratrice et Chirurgicale, CHU Hôtel-Dieu, Nantes, France
2 Service de Chirurgie Maxillo-Faciale et Stomatologie, CHU Hôtel-Dieu, Nantes, France
3 Service d'Anatomie et Cytologie Pathologiques, CHU Hôtel-Dieu, Nantes, France
* Correspondance: firstname.lastname@example.org
Accepted: 6 July 2018
Introduction: Central giant cell granuloma (CGCG) is a rare and benign intraosseous lesion that usually occurs in the mandible and the maxilla. It might be aggressive. Nowadays, several treatments exist. Observation: This case report, with a three years follow-up, was about an aggressive and recurring form of CGCG exclusively managed by surgical approach. Comments: Several pharmacologic approaches are possible (intralesional injections of glucocorticoids, administration of calcitonin, alpha-2a interferon, denosumab) and could be an interesting alternative or complement to the surgical management when CGCG is aggressive, recurring, or non resectable. Conclusion: Surgical approach is the gold standard for the treatment of CGCG but sometimes, pharmacologic approaches could be proposed. According to the scientific literature, denosumab appears as a reliable and effective treatment but more prospective studies are needed.
Key words: central giant cell ganuloma / denosumab / mandible
© The authors, 2018
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