Open Access
Table II
Study characteristics.
| SL. NO | Author | Year | Population | Outcome |
|---|---|---|---|---|
| 1 | Shahrayne Rashid et al. [12] | 2021 | Pakistan | There was increase in value of CP between normal and OSCC P-value |
| 2 | Aws. W. Abbas et al. [13] | 2014 | Iran | There was a substantial increase in serum and saliva ceruloplasmin levels of OLP patients group as compared to controls (P < 0.01). |
| 3 | Ajay Chandran et al. [9] | 2020 | India | Serum ceruloplasmin levels were found to be raised in all the three groups including oral leukoplakia, OSMF and OSCC patients as compared to the controls and thus, can be used as a potential biomarker. |
| 4 | Victor I et al. [14] | 2012 | Nigeria | There is an increase in CP levels compared to the normal. Involvement of ceruloplasmin, an angiogenic acute phase protein, in OSCC suggests a role in tumor proliferation. |
| 5 | Manika Singh et al. [15] | 2015 | India | Increased levels of copper and ceruloplasmin (<0.05) in patients with OSMF, leukoplakia, and oral cancer was observed when compared with the controls. |
| 6 | Manisha B Patil et al. [16] | 2021 | India | The study revealed that serum ceruloplasmin levels were found to be raised in all three. study groups including oral leukoplakia, OSMF and OSCC as compared to the controls while the results were found to be statistically significant. |
| 7 | Mathwe O Mampilly et al. [6] | 2021 | India | Antioxidants are an important defense system against free radical damage to cells. Ceruloplasmin and selenium levels in serum could be used as disease markers in leukoplakia and squamous cell carcinoma. |
| 8 | Palak H Shah et al. [17] | 2017 | India | The serum ceruloplasmin levels were significantly increased in OSMF, OL and NS groups as compared to healthy control groups. |
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