Open Access
Table II
General overview of the included studies.
| Interventions | Participants | Collected outcomes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Country | Settings | Design | N° of centres | Follow-up (Months) |
External funding (Type) |
Test | Control | Adjunctive treatments | N | Analysed | Implant failures | Adverse events | Post-op pain (VAS) |
|
| Esposito et al. [22] | Italy | Private practice |
Parallel | 11 | 4 | No (only free antibiotic and placebo tablets donated by Merck Generics Italia) |
Amoxicillin 2 g administered orally 1 h before the procedure |
Placebo administered orally 1 h before the procedure |
Oral hygiene training Debridement Chlorhexidine mouthwash before the operation and postoperatively for one week |
330 | 316 | Yes | Yes | No |
| Anitua et al. [23] | Spain | Private practice |
Parallel | 8 | 3 | Yes (Implant Company: BTI) |
Amoxicillin 2 g administered orally 1 h before the procedure |
Placebo administered orally 1 h before the procedure |
Oral hygiene training Debridement Chlorhexidine mouthwash before the operation and postoperatively for one week |
105 | 105 | Yes | Yes | No |
| Esposito et al. [25] | Italy | Private practice |
Parallel | 10 | 4 | No (only free antibiotic and placebo tablets donated by Merck Generics Italia) |
Amoxicillin 2 g administered orally 1 h before the procedure |
Placebo administered orally 1 h before the procedure |
Oral hygiene training Debridement Chlorhexidine mouthwash before the operation and postoperatively for one week |
509 | 506 | Yes | Yes | No |
| Tan et al. [26] | International | University | Parallel | 7 | 2 | Supported by a research grant of the ITI Foundation (Project 616-2009) and the Clinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz, Switzerland. |
Group 1: Amoxicillin 2 g administered orally 1 h before the procedure Group 2 Amoxicillin 2 g administered orally immediately after the surgery Group 3 Amoxicillin 2 g administered orally 1 h before the procedure and 500 mg administered orally three times a day on the second and third days |
Placebo administered orally 1 h before the procedure |
Not reported | 329 | 329 | Yes | Yes | Yes |
| Nolan et al. [27] | Ireland | University | Parallel | 1 | 4 | Not reported | Amoxicillin 3 g administered orally 1 h before the procedure |
Placebo administered orally 1 h before the procedure |
Oral hygiene training Debridement Chlorhexidine mouthwash before the operation and postoperatively for one week |
71 | 55 | Yes | Yes | Yes |
| Momand et al. [24] | Sweden | University and Hospital |
Parallel | 7 | 6 | Supported by grants from Skåne Regional Council, Sweden and Magn. Bergvalls Stiftelse, Sweden. | Amoxicillin 2 g administered orally 1 h before the procedure |
Placebo administered orally 1 h before the procedure |
Not reported | 474 | 473 | Yes | Yes | No |
| Santamaría Arrieta et al. [28] | Spain | University | Parallel | 1 | 2 | Supported by the Instituto de Salud Carlos III through the project “PI18/00809′′ (Co-funded by European Regional Development Fund/European Social Fund; “A way to make Europe”/”Investing in your future”) | Clindamycin 600 mg (two capsules) administered orally 1 h before the procedure |
Placebo administered orally 1 h before the procedure |
Not reported | 62 | 62 | Yes | Yes | Yes |
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