What is the effectiveness of antibiotic prophylaxis in preventing early complications following implant surgery? a systematic review

Jeanne Dubedout; Gian Marco Podda; Mathilde Fénelon; Jean-Christophe Fricain; Virginie Chuy; Sylvain Catros

doi:10.1051/mbcb/2025032

Home

All issues

Volume 31 / No 4 (2025)

J Oral Med Oral Surg, 31 4 (2025) 29

Abstract

Open Access

Issue		J Oral Med Oral Surg Volume 31, Number 4, 2025


Article Number		29
Number of page(s)		11
DOI		https://doi.org/10.1051/mbcb/2025032
Published online		26 September 2025

J Oral Med Oral Surg 2025;31:29

Systematic Review

What is the effectiveness of antibiotic prophylaxis in preventing early complications following implant surgery? a systematic review

Jeanne Dubedout¹^,a, Gian Marco Podda²^,3^,a^,*, Mathilde Fénelon¹^,2, Jean-Christophe Fricain¹^,2, Virginie Chuy¹^,2 and Sylvain Catros¹^,2

¹ UFR des Sciences Odontologiques, Univ. Bordeaux, 33000 Bordeaux, France
² CHU Bordeaux, Department of Oral Surgery, 33076 Bordeaux, France
³ Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy
⁴ CHU Bordeaux, Department of Odontology, 33076 Bordeaux, France

^* Correspondence: g.m.podda@hotmail.it

Received: 13 January 2025
Accepted: 4 August 2025

Abstract

Introduction: This systematic review of double-blind randomized controlled trials (RCTs) aimed to answer the following question: “Is antibiotic prophylaxis administered prior to implant surgery, in comparison with a placebo, effective in preventing early osseointegration complications and failure in immunocompetent patients?”. Materials and methods: A systematic review was carried out using the electronic databases PubMed, Scopus, and Web of Science, searching for articles published up to May 2023. Study selection and data extraction were performed in a double-blind manner. The primary outcome assessed was early implant failure within the first 6 months after surgery. Secondary outcomes includes: surgical complications, patient-reported adverse events and postoperative pain level. The risk of bias was evaluated with the RoB 2 tool. Results: Seven RCTs were included, encompassing a total of 1,846 participants. Two trials involved patients undergoing simultaneous bone grafting during implant placement. Six studies administered amoxicillin, while one used clindamycin. None of the trials reported statistically significant differences in implant stability or postoperative complications between the antibiotic and placebo groups (p > 0.05). Conclusion: Antimicrobial resistance remains a critical public health concern. The findings of this systematic review do not support the routine use of antibiotic prophylaxis in healthy patients undergoing implant surgery.

Key words: Antibiotic prophylaxis / dental implant / antimicrobial resistance / systematic review / peri-implantitis / osseointegration

^a

J Dubedout and GM Podda contributed equally to this work.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.