Open Access
Table I
Study Design.
| Study | Study design | Country | Age Mean + SD | Number of patients | Test group | Control group | Medical condition | Surgical procedure | Region/ Tooth |
|---|---|---|---|---|---|---|---|---|---|
| Radhakrishna et al., 2022 [17] | Randomized split-mouth study | India | 57.98 + 16.31 | 54 (39 male and 15 female) | 54 | 54 | Patients on antithrombotics | Simple non-traumatic extraction was performed for 2 teeth or more on the contralateral side in the same arch. In some instances, multi-rooted teeth were used for comparison when a contralateral tooth was unavailable. | Not reported |
| Sáez-Alcaide et al., 2020 [15] | Split-mouth randomized placebo-controlled trial | Spain | 22.94 + 4.24 | 36 (13 male and 23 female) | 36 | 36 | None | A surgical procedure was performed by raising a mucoperiosteal flap using an envelope-shaped incision from the lower second molar with vertical release on the ramus. After the tooth was extracted, the bone was irrigated with normal saline, and the flap was sutured. | Mandibular third molar |
| Pippi et al., 2016 [18] | Randomized controlled trial | Italy | 73.9 + 7.41 | 20 (10 male and 10 female) | 20 | 20 | patients on anti-platelet treatment | Routine tooth extractions were carried out in a single session by an experienced operator (PR) using local anesthesia with 3% mepivacaine without vasoconstrictor. Each patient undergoes an extraction of two teeth during the same visit. | Not reported |
| Lope- Lopez et al., 2015 [16] | Mono-center, prospective, randomized, controlled crossover study | Spain | 34.25 + 7.78 | 47 (22 male and 25 female) | 28 | 19 | None | Standardized protocols for teeth extraction methods and suturing were followed to perform surgical procedures. The difficulty of extraction was assessed using orthopantomography and classified according to the Koerner index. | Mandibular impacted third molars teeth |
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