Saw cuts from the biopsy and their histomorphometric analysis with digital labeling. Soft tissue is stained blue (undecalcified ground section, stained with azure II and pararosaniline, original magnification x50). Digital labeling of Bio-Oss granules (green), newly formed bone (red) and older bone (yellow). a) control sinus at T0, characterized by a peripheral new bone formation around Bio-oss particles; b) test sinus at T0, new bone formation was found through Bio-oss particles; c) control sinus at T1, Bio-oss particles were still present; d) test sinus at T1, no Bio-oss particles were found, only a micrometer fragment of Bio-oss particle was visible.