Open Access
Table II
Details of population, study groups and outcome (PICO) of included studies.
| S. No | Study (Adjuvant/Substitute therapy) |
Population | Intervention | Control/ Comparator group |
Primary Outcome | Secondary Outcome |
|---|---|---|---|---|---|---|
| Randomized controlled trial | ||||||
| 1. | Mulk BS et al. 2013 India [23] (Adjuvant) |
Total = 40 Group I (Pentoxyfilline)– 20 Group II (Spirulina) − 20 |
Spirulina −0.5gm capsules orally twice daily + mouth opening exercises for 20 min daily. Duration −3 months |
Pentoxyfilline − 400 mg orally twice daily + mouth opening exercises for 20 min daily Duration −3 months |
Mouth opening − SNSD Burning sensation − Spirulina group showed SSD |
Tongue protrusion − SNSD |
| 2 | Patil S et al. 2014 India[24] (Substitute) |
Total = 68 Group I(Spirulina) − 34 Group II(Lycopene) − 34 |
Spirulina − 500 mg capsules orally in two divided dosage Duration −3 months |
Lycopene − 8 mg lycopene (Lycored™, Jagsonpal Pharmaceuticals, New Delhi) in 2 divided doses of 4 mg Duration −3 months |
Mouth opening − Lycopene group showed SSD Burning sensation − SNSD |
Pain associated with lesion − SNSD Reduction of ulcers/ vesicles/ erosion − Spirulina group showed SSD |
| 3. | Patil S et al. 2015 Saudi Arabia [25] (Substitute) |
Total = 48 Group I(Spirulina) − 24 Group II (Aloe vera) − 24 |
Spirulina − 500 mg capsules orally in two divided dosages Duration −3 months |
Aloe vera − 5 mg aloe vera gel (Sheetal Lab, Surat) to be applied topically thrice daily Duration −3 months |
Mouth opening − Spirulina group showed SSD Burning sensation − SNSD |
pain associated with lesion − SNSD Reduction of ulcers/ vesicles/erosion − Spirulina group showed SSD. |
| 4. | Patil S et al. 2019 India [26] (Substitute) |
Total = 50 Group I (Spirulina) − 25 Group II (Oxitard)– 25 |
Spirulina–500 mg in 2 divided doses 250 mg in morning and 250 mg at night Duration- 3 months |
Oxitard −2 capsules twice daily Duration- 3 months |
Mouth opening − Oxitard group showed SSD. Burning sensation − SNSD |
Tongue Protrusion − Oxitard group showed SSD Reduction of ulcers/ vesicles/erosion − Spirulina group showed SSD. |
| Non-Randomized controlled trial | ||||||
| 5. | Shetty P et al. 2013 India [27] (Adjuvant) |
Total = 40 Group I(Spirulina) − 20 Group II(Placebo) − 20 |
Spirulina −500 mg capsules orally twice daily + biweekly steroid injection (Betamethasone 4 mg/ml, by the multiple puncture method Duration −3 months |
Placebo − Capsules twice daily + biweekly steroid injection (Betamethasone 4 mg/ml, by the multiple puncture method Duration −3 months |
Mouth opening − Spirulina group showed SSD Burning sensation − Spirulina group showed SSD |
Tongue Protrusion − Oxitard group showed SSD _______ |
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