Open Access

Table 4

Main information of the selected articles.

Year Authors Delivery biomaterial Analgesic Characterizations Clinical population Pharmacokinetic clinical trial Pain relief clinical trial Feeling of the patients
1992 U.J. Moore et al. [14] Methyl cellulose gels Aspirin
/ 2 × 12 patients (Control: aspirin/oral paracetamol) / Pain decrease at the early time
Decrease of the administered dose
Rapid efficiency
1994 U.J. Moore et al. [13] Methyl cellulose gels Morphine / 12 patients (Control: oral morphine) / No effect /
2004 R.A. Dionne et al. [10] Gelatin particles and sponges Flurbiprofene / 107 patients (Control: oral flurbiprofene) 50% decrease of the plasmatic concentration Pain decrease Good tolerability
2007 L. Perioli et al. [15] Bilayer cellulose/polyacrylic + cellulose/hydrotalcite Flurbiprofene Rapid swallowing
Good adhesion
Good maintenance on the site
Slow and sustained release, faster in vivo compared to in vitro
5 (Control: /) / / /
2007 I.A. Alsarra et al. [16] HPMC/Carbopo 934 Films Ketorolac / Rat
Human: 68 patients (Control: placebo)
/ Decrease of the edema//Pain decrease /
2009 N. Vasisht et al. [11] BEMA® (BioErodible MucoAdhesive)
FBSF (Fentanyl Buccal Soluble Film)
Fentanyl / 12 patients (Control: oral transmucosal fentanyl citrate) Maximum and cumulated concentration and absorption time higher with the film compared to the pill controls / /
2010 K. Al Hezaimi et al. [6] HPMC/polyacrylic acid gels Ketorolac / 68 patients (Control: placebo) / Pain decrease /
2011 S. Movassaghian et al. [17] HPMC et CMC tablets Amitriptyline The release and the mucoadhesion increase when the viscosity decreases 25 patients (Control: placebo) / Pain decrease compared to the placebo /
2014 G. Pickering et al. [12] Hydroalcoholic gels Paracetamol / 20 patients (Control: paracetamol IV et S) Decrease of the paracetamol concentration in blood Increase of the analgesia
Faster analgesia
Satisfaction of the patients
Slight bitter taste
2015 S.R. Rajeswari et al. [7] HPMC films Meloxicam / 60 patients (Control: /) / Pain decrease
Rapid efficiency
Good comfort
Only 1 administration
Satisfaction of the patients
Slight bitter taste

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