Open Access
Table 4
Main information of the selected articles.
| Year | Authors | Delivery biomaterial | Analgesic | Characterizations | Clinical population | Pharmacokinetic clinical trial | Pain relief clinical trial | Feeling of the patients |
|---|---|---|---|---|---|---|---|---|
| 1992 | U.J. Moore et al. [14] | Methyl cellulose gels | Aspirin Paracetamol |
/ | 2 × 12 patients (Control: aspirin/oral paracetamol) | / | Pain decrease at the early time Decrease of the administered dose Rapid efficiency |
/ |
| 1994 | U.J. Moore et al. [13] | Methyl cellulose gels | Morphine | / | 12 patients (Control: oral morphine) | / | No effect | / |
| 2004 | R.A. Dionne et al. [10] | Gelatin particles and sponges | Flurbiprofene | / | 107 patients (Control: oral flurbiprofene) | 50% decrease of the plasmatic concentration | Pain decrease | Good tolerability |
| 2007 | L. Perioli et al. [15] | Bilayer cellulose/polyacrylic + cellulose/hydrotalcite | Flurbiprofene | Rapid swallowing Good adhesion Good maintenance on the site Slow and sustained release, faster in vivo compared to in vitro |
5 (Control: /) | / | / | / |
| 2007 | I.A. Alsarra et al. [16] | HPMC/Carbopo 934 Films | Ketorolac | / | Rat Mouse Human: 68 patients (Control: placebo) |
/ | Decrease of the edema//Pain decrease | / |
| 2009 | N. Vasisht et al. [11] | BEMA® (BioErodible MucoAdhesive) FBSF (Fentanyl Buccal Soluble Film) |
Fentanyl | / | 12 patients (Control: oral transmucosal fentanyl citrate) | Maximum and cumulated concentration and absorption time higher with the film compared to the pill controls | / | / |
| 2010 | K. Al Hezaimi et al. [6] | HPMC/polyacrylic acid gels | Ketorolac | / | 68 patients (Control: placebo) | / | Pain decrease | / |
| 2011 | S. Movassaghian et al. [17] | HPMC et CMC tablets | Amitriptyline | The release and the mucoadhesion increase when the viscosity decreases | 25 patients (Control: placebo) | / | Pain decrease compared to the placebo | / |
| 2014 | G. Pickering et al. [12] | Hydroalcoholic gels | Paracetamol | / | 20 patients (Control: paracetamol IV et S) | Decrease of the paracetamol concentration in blood | Increase of the analgesia Faster analgesia |
Satisfaction of the patients Slight bitter taste |
| 2015 | S.R. Rajeswari et al. [7] | HPMC films | Meloxicam | / | 60 patients (Control: /) | / | Pain decrease Rapid efficiency |
Good comfort Only 1 administration Satisfaction of the patients Slight bitter taste |
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