Recommendation grades and scientific level of evidence according to the HAS .
|Recommendations grade||Scientific level of proof from literature|
Well established proof
|High power randomized comparative trials;|
|Meta-analysis of randomized comparative trials;|
|Analysis of well conducted studies.|
|Low power randomized comparative trials;|
|Not randomized well conducted comparative studies;|
|Low scientific proof||Level 4|
|Comparative trials with number of bias;|
|Descriptive epidemiological studies (transversal, longitudinal).|
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