Case Report

Oral consequences of toxic epidermal necrolysis in childhood: a two-case report and management challenges without medical care plan support

¹ Department of Oral and Maxillofacial Surgery, Nancy University Hospital, Nancy, France
² Department of Stomatology, Oral and Maxillofacial Surgery, Lille University Hospital, Lille, France

^* Correspondence: This email address is being protected from spambots. You need JavaScript enabled to view it.

Received: 21 July 2025
Accepted: 14 January 2026

Abstract

Toxic epidermal necrolysis (TEN), also known as Lyell’s syndrome, is a rare but severe dermatological condition for which acute-phase management is well standardized. However, the long-term sequelae—particularly oral and dental complications—remain largely underestimated. Through two clinical case reports of adults who contracted the syndrome during childhood, we highlight the significant functional and aesthetic impact of oral involvement, as well as the current limitations in the care pathway. These are further exacerbated by the lack of systematic recognition of this condition as a long-term illness (Affection de Longue Durée, ALD031) under the French healthcare system. The aim of this article is to emphasize the need for early and long-term dental monitoring in childhood-onset Lyell’s syndrome, given the predictable disruption of dental development prior to the eruption of the permanent dentition.