| Issue |
J Oral Med Oral Surg
Volume 32, Number 1, 2026
|
|
|---|---|---|
| Article Number | 3 | |
| Number of page(s) | 5 | |
| DOI | https://doi.org/10.1051/mbcb/2026002 | |
| Published online | 17 March 2026 | |
Case Report
Primary intraosseous squamous cell carcinoma mimicking an odontogenic cyst: a case-report
Department of Oral Surgery, Center of Dental Care, Rennes, France, 2 Rue Henri le Guilloux cedex, 35000 Rennes
* Correspondence: This email address is being protected from spambots. You need JavaScript enabled to view it.
Received:
2
July
2025
Accepted:
7
January
2026
Abstract
Introduction: A rare case of primary intraosseous squamous cell carcinoma (PIOSCC) emerging from an apical cyst is presented. Main symptoms and findings: An 80-year-old woman presented with an asymptomatic radiolucent lesion in the mandibular premolar region, identified during routine radiographic screening. The lesion was associated with chronic inflammation and prior endodontic treatment. Diagnoses, interventions, and outcomes: Initial management included enucleation of the lesion with extraction of the involved teeth. Histopathology revealed a moderately differentiated PIOSCC. Following oncological evaluation, the patient underwent curative surgery and was scheduled for adjuvant therapy. Conclusion: Although apical cysts are typically benign, rare malignant transformation underscores the necessity for histopathological analysis of all excised lesions. This highlights the importance of vigilant diagnostic and therapeutic approaches for seemingly benign lesions.
Key words: intraosseous squamous cell carcinoma / apical cyst / mandibular lesion / case report / odontogenic malignancy
© The authors, 2026
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