J Oral Med Oral Surg
Volume 26, Number 4, 2020
|Number of page(s)||7|
|Published online||28 August 2020|
Reproducibility of tissue autofluorescence for screening potentially malignant disorders
Pôle d'Odontologie et de Santé Buccale, CHU de Bordeaux, Bordeaux, France
2 Inserm, U1026, Tissue Bioengineering, University Bordeaux Segalen, Bordeaux Cedex, France
3 Unité de Soutien Méthodologique à la recherche clinique et épidémiologique, Pôle de Santé Publique, CHU de Bordeaux, Bordeaux, France
4 CHU de Bordeaux, Pôle de Santé Publique, Unité de Soutien Méthodologique à la recherche clinique et épidémiologique, University of Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France
* Correspondence: email@example.com
# Co first author.
Accepted: 17 July 2020
Introduction: Direct tissue autofluorescence (AF) visualization devices such as VELscope® are gaining interest to improve early detection of oral potentially malignant disorders (OPMD) and cancers. The main objective of this study was to assess inter-observer reproducibility of incandescent light (IL) and AF observations for OPMD and cancer. Materials and methods: High risk patients (exposed to alcohol or tobacco) were screened by two independent operators with a conventional oral examination (IL) followed by AF examination. The primary endpoint was the inter-observer agreement on the decision to biopsy assessed by kappa coefficients.Accuracy of IL and AF were estimated by the relative true positive rate (RTPR, increase of sensitivity), relative false positive rate (RFPR, loss of specificity) and their ratio. Results: 179 patients were included. 833 lesions were identified after IL and AF. Indication for biopsy was retrieved for 41 patients (61 lesions). Inter-observer agreement on the indications for biopsy was 93.3% after IL (Kappa coefficient 0.88 [0.80, 0.97]) and 96.1% after IL and AF (Kappa coefficient 0.78 [0.66, 0.90]). RTPR was 1.2, RFPR was 1 and their ratio was 1.2. Conclusion: IL and AF examination has shown good inter-observer reproducibility. Adjunction of AF allowed diagnosing more leukoplakia without dysplasia.
Key words: oral cancer early detection / oral mucosa / autofluorescence
© The authors, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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