Table II
Summary of published concentrations by biomarkers and by population groups.
| Biomarkers | N studies | Δ salivary concentration pop cancerous | Δ salivary concentration pop pré-cancerous | Variation of blood concentration | Variation of tissue concentration |
|---|---|---|---|---|---|
| Tumor markers | |||||
| CEA (Carcinoembryonic antigen) | 1 | ↑* | – | – | – |
| Cyfra 21–1 (Cytokeratin fraction 21–1) | 3 | ↑* | ↑ | ↑* | = |
| Metabolic markers | |||||
| Zinc | 2 | ↓*A/B | ↓*A/B | ↓*A | – |
| Copper | 1 | ↑*B | ↑*B | – | – |
| Iron | 1 | ↓ | ↓ | – | – |
| GSH (Gluthatione) | 2 | ↓*A | ↓*A | ↓*A | – |
| SOD (Superoxyde dismutase) | 2 | = | – | ↓ | – |
| LDH (Lactate dehydrogenase) | 3 | ↑ | ↑ | – | – |
| SialicAcid (N-acetyl neuraminic acid) | 4 | ↑* | ↑* | ↑* | – |
| 8-OHdG (8-hydroxy-2-deoxyguanosine) | 1 | ↑*C | ↑*C | – | – |
| MDA (malondialdehyde) | 1 | ↑*C | ↑*C | – | – |
| Vitamin C (acid ascorbic) | 2 | ↓*C | ↓*C | ↓* | – |
| Vitamin E | 1 | ↓*C | ↓*C | – | – |
| Proteome | |||||
| LDOC 1 | 1 | = | – | – | – |
| Glycine | 1 | ↓* | ↓ | – | – |
| Proline | 1 | ↓* | ↓ | – | – |
| CA19-9 | 1 | = | – | – | – |
| Amylase | 1 | ↓ | ↓ | – | – |
| S100A8 | 1 | ↑* | – | – | ↑* |
| IL 4 | 1 | ↑D | – | – | – |
| IL 6 | 2 | ↑* | ↑ | = | – |
| IL 8 | 2 | ↑* | ↑* | ↑* | – |
| IL 10 | 1 | ↑D | – | – | ↑ |
| IL 13 | 1 | ↑D | – | ↑ | – |
| CD 44 | 1 | ↑ | – | ↑ | – |
| CD44v6 | 1 | ↑*E | ↑ | = | – |
| CD44v10 | 1 | ↑*E | ↑ | – | – |
| RETN (Resistin) | 1 | ↑ | – | – | – |
| CCNA1 | 1 | ↑F | – | – | – |
| DAPK | 1 | ↑F | – | – | – |
| DCC | 1 | ↑F | – | – | – |
| TIMP 3 | 1 | ↑F | – | – | – |
| EGFR (Epidermal growth factor receptor) | 1 | ↑* | – | ↓* | – |
| AKR1B10 (Aldo-keto reductase family 1 member B10) | 1 | ↑* | – | – | – |
| MMP 9 | 1 | ↑* | – | ↓ | – |
| SYNE 1 | 1 | ↓E | – | – | – |
| Global proteome | 2 | ↑ou↓ | – | – | – |
| Transcriptome | |||||
| miR-139-5p | 1 | ↓* | – | – | – |
| miARN 145 | 1 | ↓* | ↓* | – | – |
| miARN 184 | 1 | ↑* | ↑* | – | – |
| miR34a | 1 | ↓*E | ↓ | = | – |
| OAZ mARN | 1 | ↑G | ↑ | – | – |
| IL8 mARN | 1 | ↑*G/H | ↑ | – | – |
| IL1B mARN | 1 | ↑*G/H | ↑ | – | – |
| SAT mARN | 1 | ↑* | – | ↑ | ↑ |
| Transgelin mARN | 1 | ↑G | ↑ | – | – |
| IL 1-RA | 1 | ↑D | – | – | – |
Δ = variation; ↑ = increase of concentration; D = decrease of concentration; without asterisk = p > 0.05; with asterisk = p < 0.05; = : no significant variation; A à H = Proposed biomarkers combinations (A: Zinc- GSH/B: Zinc − Copper/ C: 8-OHdG- MDA- Vitamin C − Vitamin E/D: IL4 − IL10 − IL13 − IL1RA/E: CD44v − SYNE1 − miR34a/F: CCNA1 − DAPK − DCC − TIMP3/G: OAZ mRNA − SAT mRNA − IL8 mRNA − IL1B mRNA/H: SAT − IL8).
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